Pierzina returned to the house in Big Brother All-Stars, being reunited with three members of her Sovereign Six allies. In this season, Janelle set the record for most individual competitions won in a single season, with 9 (4 HoH's & 5 PoV's). Once again, she placed third. She also developed a flirtmance with Will Kirby where the two formed a connection as the season progressed but ultimately stayed friends due to both being in relationships outside the house. At the finale of the season, Janelle was awarded $25,000 as the winner of the Fan Favorite Award.
Janelle returned along with three former houseguests for Big Brother 14, as part of the coaches twist. During Week 3, Janelle re-entered the game for her third time. Janelle was the fourth houseguest evicted, placing twelfth out of sixteen, after Mike "Boogie" Malin convinced Danielle Murphree to backdoor Janelle, allowing her no chance to save herself.
Because of her competition prowess, she is regarded as the greatest female houseguest and one of the greatest players in the history of the show.
Fan favorite Janelle Pierzina returns to BIG BROTHER for the third summer. She first competed on BIG BROTHER in Season 6, when she finished in third place, but she took home “America’s Favorite Player.” She also finished in third place of season 7, BIG BROTHER: ALL-STARS. This very physical and competitive player sees returning as a mentor as a positive. According to Janelle she’s “good at keeping people together and getting people on my side… the coaching dynamic is perfect for my gameplay.” While this 32-year-old is returning as a mentor to play her own game, she hopes to make it past third place this time. Her strategy to do so: “try and keep my team together as much as possible and possibly pick up some other alliance members along the way.” You can be sure that her husband and baby girl home in Minnesota will be rooting for her this summer.
On June 11, 2009 Janelle announced her engagement to Jess DeSanto. The two married in 2010.
Janelle gave birth to a baby girl on December 14th, 2011 and named her Violet Anne DeSanto.
On August 10th, 2013, Janelle gave birth to a baby boy named Lincoln William DeSanto, who shares the same birthday with one of Janelle's former alliance members of the Sovereign Six, Kaysar Ridha.
Her third child, Stella Rose DeSanto, was born on September 26th, 2014.
Janelle Pierzina competed on a Big Brother Primetime Special of The Price is Right that aired on May 24, 2016. Janelle and her partner, Geoffrey, won a hammock, hot tub, and pair of patio heaters and made it to the Showcase Showdown. However, They lost the Showdown to Brian and former houseguest, Will Kirby. The charity Janelle was playing for was Cycle for Survival.
Janelle is now a realtor.
She was the first person to lose his/her partner in Big Brother 6, as Ashlea Evans her ex-roommate and secret partner was evicted first.
Janelle won every America's Choice during her stay on Big Brother 6.
She is currently one of four people to be evicted three times along with Brendon Villegas, Victor Arroyo and fellow BB6/BB7 houseguest Kaysar Ridha. She is the only female and only houseguest to be evicted in three different seasons.
Janelle holds the record for the most individual competitions won in a single season with 9, by winning 4 Head of Household's and 5 Power of Veto's. Janelle also holds the record for most individual competitions won in multiple seasons with 6 HOH's (tied with Rachel Reilly), 7 POV's, and 2 Coaches Competitions– making a total of 15 competitions.
Janelle was the only houseguest to win challenges on Team Janelle in Big Brother 14.
Janelle is the only female member of the Sovereign Six alliance to return for another season.
Janelle has used the Power of Veto more than any other HouseGuest (6 out of 7 wins)
Janelle has also been a favorite houseguest of many future houseguests most notably Rachel Reilly and Britney Haynes who Janelle would later compete against.
Janelle became the first female to win more than two PoVs in a single season.