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Week 1
On Day 0, JK Labajo,Yassi Pressman, Jinri Park and Nikko Natividad & McCoy DeLeon were introduced as the first five celebrity housemates. As part of the season's twist, they were flown to Ho Chi Minh City, Vietnam and entered on the Big Brother House in Vietnam on Day 1; however, only McCoy, Nikko and Yassi were only able to depart as Jinri, JK and Hideo got delayed due to visa and immigration card issues.

After arriving in Vietnam, McCoy, Nikko and Yassi then entered the Vietnamese Big Brother House along with Chacha, Elisse Joson and Nonong Ballinan. Two Vietnamese actors; Chi Buu Phan who was actually a Big Brother Vietnam contestant, Annie Hoang Anh, a Vietnamese celebrity and Thuy Nguyen entered the House; their task was to pretend that they were the current occupants and were the last three housemates of Big Brother Vietnam who just got back to the house after finishing a task in the outside world in order to challenge the housemates on how to handle the situation of being an intruder in a non-English speaking country. Despite having the language barrier, the celebrity housemates tried to communicate with the Vietnamese guests the best the could.

Throughout their stay inside the Big Brother Vietnam house, they were obliged to follow certain Vietnamese customs and traditions. They were obliged to use chopsticks all the time, to leave all their footwear outside garden area, and the house must be clean and orderly at all times. In addition to that, the Vietnamese Big Brother spoke to them instead of the Big Brother they knew in the Philippines, giving them a difficult time to understand what he says and kept on longing to the Big Brother they knew. It wasn't until Day 3 that Filipino Big Brother started talking to the celebrity housemates.

On Day 2, Jinri Park, Juan Karlos Labajo and Hideo Muraoka were able to resolve the issues and were able to fly to Vietnam; the three entered the House that morning, while being chained and blindfolded. Due to this, the housemates had to unchain them within 30 minutes using the 3 correct keys among the 77 keys scattered around the House; they were successful. On Day 3, Thuy returned; in order to secure her spot as a regular housemate, she was tasked to pretend that she had won Big Brother Vietnam, that she has to temporarily stay as a house guest, and that she has to help them in their special task. The housemates must not discover her real identity so she wasn't allowed to speak Tagalog and English and must speak only Vietnamese at all times.

Week 2
On Day 10, Hideo, Jinri, Yassi and JK were nominated. On Day 11, Chacha decided to voluntarily exit during their first eviction night; note that Hideo was supposedly the one to exit the House after having the poorest performance in the Ligtask Challenge.

On Day 15, the housemates have won their 6th and last Lucky task; with this, Thuy revealed her true self. Jinri was temporarily allowed to leave the House due to reasons kept confidential; her exit was not considered as voluntary. In the morning of Day 16, Big Brother toured the housemates in the Mekong River. By the afternoon, after more than two weeks in Vietnam, Big Brother announced that they will be leaving the Vietnamese Big Brother House and will return to the Philippines.

Weeks 3 & 4
On Day 17, with the exception of JK, the celebrity housemates entered the Pinoy Big Brother House. Later on, Big Brother revealed that only two of them will only make it to the Finale; he also told them that they will encounter many challenges determined by picking a ball among the other Balls of Fate placed inside a Big Tambiolo. Yassi was tasked to choose the first ball; their first task was that they were only allowed to bring one luggage from eight luggage they have; they picked Nonong's luggage. After the entry of the housemates, disguised as a hooded face ninja, Jerome Ponce entered the House as a house guest in order to assist Big Brother in the housemates' challenges and to fix the thing between him and Elisse. On Day 18, Elisse picked the second ball which showed an image of a basket; the image would mean that they will get a basket of eggs, sweet potatoes and bitter gourds as their food. They had to ration it until Big Brother gives them another set of food supply. Meanwhile, McCoy was informed by Big Brother that the hooded face ninja was Jerome and that he has to help bring him to their bedroom without the female housemates noticing them; he was allowed to tell the task and ask for help with the other male housemates.

On Day 19, McCoy and the other male housemates continued their task in hiding Jerome from the females. Later that day, the female housemates were blind-folded for 4 hours; this gave Jerome the opportunity to freely roam the House. JK returned to the House; he was introduced by Big Brother to Jerome in the Confession Room. He was also told about the male housemates' task. Later on, the still blind-folded female housemates entered the Confession Room one by one; they were tasked to identify JK and Jerome. Each of the female housemates perfectly identified JK; while Jerome was only identified by Elisse. Due to this, JK was able to enter the House; Jerome, who was not able to enter the House, was given the chance to write a letter to Elisse. After Elisse read the letter, she was given the decision whether she would be willing to talk with him. On the early hours of Day 20, she decided to talk and both were able to do so. Their conversation led to the closure to their failed relationship. On Day 22, Jinri won one of the two Lucky Stars granting her to continue in hopes of becoming the big winner of this season. On Day 23, McCoy & Nikko later were revealed to get the last Lucky Star and able to continue with Jinri. The non-finalist celebrity housemates later exited the House.